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A Bayesian inference of P(λ1<λ2) for two Poisson parameters
Authors:Youhei Kawasaki  Etsuo Miyaoka
Institution:1. Biostatistics Group, Data Science Department, Development Division , Mitsubishi Tanabe Pharma Corporation , 2-2-6 Nihonbashi-Honcho, Chuo-ku, Tokyo , 103-8405 , Japan;2. Graduate School of Science , Tokyo University of Science , 1-3 Kagurazaka, Shinjuku-ku, Tokyo , 162-8601 , Japan;3. Department of Mathematics , Tokyo University of Science , 1-3 Kagurazaka, Shinjuku-ku, Tokyo , 162-8601 , Japan
Abstract:The statistical inference drawn from the difference between two independent Poisson parameters is often discussed in the medical literature. However, such discussions are usually based on the frequentist viewpoint rather than the Bayesian viewpoint. Here, we propose an index θ=P(λ1, post2, post), where λ1, post and λ2, post denote Poisson parameters following posterior density. We provide an exact and an approximate expression for calculating θ using the conjugate gamma prior and compare the probabilities obtained using the approximate and the exact expressions. Moreover, we also show a relation between θ and the p-value. We also highlight the significance of θ by applying it to the result of actual clinical trials. Our findings suggest that θ may provide useful information in a clinical trial.
Keywords:gamma distribution  hypergeometric series  Poisson distribution  posterior distribution  $p$-value
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