A numerical study for comparing two response-adaptive designs for continuous treatment effects |
| |
Authors: | Anna Maria Paganoni Piercesare Secchi |
| |
Institution: | (1) Dipartimento di Matematica “F. Brioschi”, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20123 Milano, Italy |
| |
Abstract: | We study two sequential, response-adaptive randomized designs for clinical trials; one has been proposed in Bandyopadhyay
and Biswas (Biometrika 88: 409–419, 2001) and in Biswas and Basu (Sankhya Ser B 63:27–42, 2001), the other stems from the
randomly reinforced urn introduced and studied in Muliere et al. (J Stat Plan Inference 136:1853–1874, 2006a). Both designs
can be used in clinical trials where the response from each patient is a continuous variable. Comparison is conducted through
numerical studies and along a new guideline for the evaluation of a response-adaptive design. |
| |
Keywords: | Response adaptive designs Clinical trials Urn schemes |
本文献已被 SpringerLink 等数据库收录! |
|