Notes on likelihood intervals and profiling

In many applications, decisions are made on the basis of function of parameters g(θ). When the value of g(theta;) is calculated using estimated values for te parameters, its is important to have a measure of the uncertainty associated with that value of g(theta;). Likelihood ratio approaches to finding likelihood intervals for functions of parameters have been shown to be more reliable, in terms of coverage probability, than the linearization approach. Two approaches to the generalization of the profiling algorithm have been proposed in the literature to enable construction of likelihood intervals for a function of parameters (Chen and Jennrich, 1996; Bates and Watts, 1988). In this paper we show the equivalence of these two methods. We also provide and analysis of cases in which neither profiling algorithm is appropriate. For one of these cases an alternate approach is suggested Whereas generalized profiling is based on maximizing the likelihood function given a constraint on the value of g(θ), the alternative algorithm is based on optimizing g(θ) given a constraint on the value of the likelihood function.