A Simulation Study Comparing Modeling Approaches in an Illness-Death Multi-State Model |
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Authors: | Luís Meira-Machado Susana Faria |
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Institution: | Department of Mathematics and Applications and Center of Mathematics of the University of Minho , Guimar?es , Portugal |
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Abstract: | In many medical studies, there are covariates that change their values over time and their analysis is most often modeled using the Cox regression model. However, many of these time-dependent covariates can be expressed as an intermediate event, which can be modeled using a multi-state model. Using the relationship of time-dependent (discrete) covariates and multi-state models, we compare (via simulation studies) the Cox model with time-dependent covariates with the most frequently used multi-state regression models. This article also details the procedures for generating survival data arising from all approaches, including the Cox model with time-dependent covariates. |
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Keywords: | Markov process Multi-state model Proportional hazards model Simulation study Time-dependent covariate |
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