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Nonparametric Modeling Auxiliary Covariates in Random Coefficient Models
Authors:Jianwei Chen  Xiaofei Wang  Dai Yang  Boming Fan
Institution:1. Department of Mathematics and Statistics , San Diego State University , San Diego , California , USA jchen@sciences.sdsu.edu;3. Department of Biostatistics and Bioinformatics , Duke University School of Medicine , Durham , North Carolina , USA;4. Department of Mathematics and Statistics , San Diego State University , San Diego , California , USA
Abstract:Random coefficient model (RCM) is a powerful statistical tool in analyzing correlated data collected from studies with different clusters or from longitudinal studies. In practice, there is a need for statistical methods that allow biomedical researchers to adjust for the measured and unmeasured covariates that might affect the regression model. This article studies two nonparametric methods dealing with auxiliary covariate data in linear random coefficient models. We demonstrate how to estimate the coefficients of the models and how to predict the random effects when the covariates are missing or mismeasured. We employ empirical estimator and kernel smoother to handle a discrete and continuous auxiliary, respectively. Simulation results show that the proposed methods perform better than an alternative method that only uses data in the validation data set and ignores the random effects in the random coefficient model.
Keywords:Auxiliary covariate  Empirical estimator  Kernel smoother  Measurement error  Missing data  Random coefficient models
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