Determination of the Selection Statistics and Best Significance Level in Backward Stepwise Logistic Regression

The weighted generalized estimating equation (WGEE), an extension of the generalized estimating equation (GEE) method, is a method for analyzing incomplete longitudinal data. An inappropriate specification of the working correlation structure results in the loss of efficiency of the GEE estimation. In this study, we evaluated the efficiency of WGEE estimation for incomplete longitudinal data when the working correlation structure was misspecified. As a result, we found that the efficiency of the WGEE estimation was lower when an improper working correlation structure was selected, similar to the case of the GEE method. Furthermore, we modified the criterion proposed by Gosho et al. (2011 Gosho, M., Hamada, C. and Yoshimura, I. 2011. Criterion for the selection of a working correlation structure in the generalized estimating equation approach for longitudinal balanced data. Communications in Statistics -Theory and Methods, 40: 3839–3856. Taylor &; Francis Online], Web of Science ®] , Google Scholar]) for selecting a working correlation structure, such that the GEE and WGEE methods can be applied to incomplete longitudinal data, and we investigated the performance of the modified criterion. The results revealed that when the modified criterion was adopted, the proportion that the true correlation structure was selected was likely higher than that in the case of adopting other competing approaches.