Sample Size Calculation and Power Analysis of Changes in Mean Response Over Time |
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| Authors: | Honghu Liu Tongtong Wu |
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| Institution: | 1. Division of General Internal Medicine &2. Health Services Research , UCLA David Geffen School of Medicine , Los Angeles, California, USA hhliu@ucla.edu;4. Department of Epidemiology and Biostatistics , University of Maryland , College Park, Maryland, USA |
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| Abstract: | Despite tremendous effort on different designs with cross-sectional data, little research has been conducted for sample size calculation and power analyses under repeated measures design. In addition to time-averaged difference, changes in mean response over time (CIMROT) is the primary interest in repeated measures analysis. We generalized sample size calculation and power analysis equations for CIMROT to allow unequal sample size between groups for both continuous and binary measures, through simulation, evaluated the performance of proposed methods, and compared our approach to that of a two-stage model formulization. We also created a software procedure to implement the proposed methods. |
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| Keywords: | Changes of mean response over time Power analysis Repeated measures design Sample size calculation |
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