Sufficient reduction methods for multivariate time-dependent health surveillance data

ABSTRACT

Early detection with a low false alarm rate (FAR) is the main aim of outbreak detection as used in public health surveillance or in regard to bioterrorism. Multivariate surveillance is preferable to univariate surveillance since correlation between series (CBS) is recognized and incorporated. Sufficient reduction has proved a promising method for handling CBS, but has not previously been used when correlation within series (CWS) is present. Here we develop sufficient reduction methods for reducing a p-dimensional multivariate series to a univariate series of statistics shown to be sufficient to monitor a sudden, but persistent, shift in the multivariate series mean. Correlation both within and between series is taken into account, as public health data typically exhibit both forms of association. Simultaneous and lagged changes and different shift sizes are investigated. A one-sided exponentially weighted moving average chart is used as a tool for detection of a change. The performance of the proposed method is compared with existing sufficient reduction methods, the parallel univariate method and both VarR and Z charts. A simulation study using bivariate normal autoregressive data shows that the new method gives shorter delays and a lower FAR than other methods, which have high FARs when CWS is clearly present.