Repeated measurements,log likelihood ratio tests and small samples

Various models have previously been proposed for data comprising m repeated measurements on each of N subjects. Log likelihood ratio tests may be used to help choose between possible models, but these tests are based on distributions which in theory apply only asymptotically. With small N , the log likelihood ratio approximation is unreliable, tending to reject the simpler of two models more often than it should. This is shown by reference to three datasets and analogous simulated data. For two of the three datasets, subjects fall into two groups. Log likelihood ratio tests confirm that for each of these two datasets group means over time differ. Tests suggest that group covariance structures also differ.