Tables of critical values for two group interim analyses

Tables of critical values are given, which can be used to execute interim analyses in clinical trials involving two groups when the joint distribution of the test statistics can be approximated by a multivariate normal distribution. Critical values are given for both the one and two interim analyses cases for a variety of partitions of α and correlation structures. Results of power calculations are presented, which reflect the effects of both the correlation structure and partitions of α.Several examples are given, which illustrate how to apply the tables to a variety of experiments