Bayesian and Classical Approaches for Hypotheses Testing in Trisomies

We introduce classical approaches for testing hypotheses on the meiosis I non disjunction fraction in trisomies, such as the likelihood-ratio, bootstrap, and Monte Carlo procedures. To calculate the p-values for the bootstrap and Monte Carlo procedures, different transformations in the data are considered. Bootstrap confidence intervals are also used as a tool to perform hypotheses tests. A Monte Carlo study is carried out to compare the proposed test procedures with two Bayesian ones: Jeffreys and Pereira-Stern tests. The results show that the likelihood-ratio and the Bayesian tests present the best performance. Down syndrome data are analyzed to illustrate the procedures.