Institution: | 1. Institute of Medical Biometry and Medical Informatics, University Hospital of Freiburg , Freiburg , Germany wfs@imbi.uni-freiburg.de;3. Institute of Medical Biometry and Medical Informatics, University Hospital of Freiburg , Freiburg , Germany;4. Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences , University of Leicester , Leicester , UK;5. Cancer Research UK/NHS , Centre for Statistics in Medicine , Oxford , UK |