Small-sample behavior of weighted least squares in experimental design applications

In experimental design applications unbiased estimators s_i ² of the variances σ_i ² are possible. These estimators may be used in Weighted Least Squares (WLS) when estimating the parameters β. The resulting small-sample behavior is investigated in a Monte Carlo experiment. This experiment shows that an asymptotically valid covariance formula can be used if s_i ² is based on, say, at least 5 observations. The WLS estimator based on estimators s_i ² gives more accurate estimators of β, provided the σ_i ² differ by a factor, say, 10.