Optimum treatment allocation for dual-objective clinical trials with binary outcomes |
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| Authors: | Wei Zhu Weng Kee Wong |
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| Affiliation: | Department of Applied Mathematics and Statistics , State University of New York at Stony Brook , Stony Brook, NY, 11794-3600 |
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| Abstract: | A common problem in randomized controlled clinical trials is the optimal assignment of patients to treatment protocols, The traditional optimal design assumes a single criterion, although in reality, there are usually more than one objective in a clinical trial. In this paper, optimal treatment allocation schemes are found for a dual-objective clinical trial with a binary response. A graphical method for finding the optimal strategy is proposed and illustrative examples are discussed. |
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| Keywords: | compound optimal design constrained optimal design efficiency plot: logistic regression model |
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