Semiparametric Regression Analysis of Panel Count Data with Time-Dependent Covariates and Informative Observation and Censoring Times

In this article, we extend the joint frailty models proposed by Zhao and Tong (2011 Zhao , X. , Tong , X. ( 2011 ). Semiparametric regression analysis of panel count data with informative observation times . Comput. Statist. Data. Anal. 55 : 291 – 300 .Crossref], Web of Science ®] , Google Scholar]) to panel count data with the time-dependent covariates and informative observation and censoring times. A novel estimating equation approach that does not depend on the distribution of frailty variables and the link function is proposed for estimation of parameters, and the asymptotic properties of the proposed estimators are established. Simulation studies demonstrate that the proposed inference procedure performs well. The analysis of a bladder tumor data is presented to illustrate the method.