Assessing the cumulative effects of stress: The association between job stress and allostatic load in a large sample of Chinese employees

Job stress can lead to various system dysfunctions, but until now no reliable biomarkers for its assessment have been identified. Allostatic load (AL) is an index that enables the cumulative effect on the body of chronic stress to be assessed, and is derived from a set of relevant biological measures. In this study, a 13-parameter index (building on the original 10-item index) was used to examine the relationship between job strain and AL. Participants were 1219 healthy Chinese employees. Job strain was measured using the Job Content Questionnaire, and AL was assessed by various possible stress responses, including blood pressure, cholesterol, indicators of glucose metabolism, and hormone and inflammation markers. AL in the high job strain group differed sharply from that in the low job strain group. The AL score was positively associated with age and educational level. Several individual parameters also differed between the two groups. Men scored significantly higher on AL and cardiovascular and metabolic health outcomes, whereas for women the associations appeared in the biological indicators. Analyses indicated that decision latitude (DL) and job demands were significantly related to AL. Job demands correlated significantly with the primary biological indicators and DL with the secondary health outcomes. In conclusion, this study provides evidence of the value of measuring allostatic load in assessing the chronic effects of job stress.