微刺激和自然周期中IVF和ICSI的结局分析

目的:探讨高龄?因卵巢功能减退?有诱导排卵禁忌证等反复种植失败的患者,采用克罗米芬微刺激或自然周期体外受精(in vitro fertilization,IVF)/单精子卵胞浆内注射(intracytoplasmic sperm injection,ICSI)治疗,分析关于卵母细胞质量及胚胎发育潜能的数据?方法:分析微刺激周期和自然周期不同受精方式下的实验室数据,包括获卵率?卵子成熟率?正常受精率?正常卵裂率?可移植胚胎率?优质胚胎率?妊娠率?结果:2010年1月~2012年11月,共完成IVF/ICSI治疗周期2 565个,其中克罗米芬微刺激周期1 752个,自然周期813个?随着周期数的增加,正常受精率?卵裂率?可移植胚胎率?优质胚胎率?妊娠率及临床妊娠率呈上升趋势?结论:对于卵巢功能减退?高龄?有诱导排卵禁忌证等卵巢低反应的患者,优质胚胎率低下和(或)反复移植失败的低生育力患者,使用微刺激或自然周期方案是优先选择的方案?

The laboratory result analysis of mild-stimulation or natural cycle treatment in IVF/ICSI

Objective:To investigate the quality of oocyte and embryo developmental potential of poor ovarian responders with ovarian dysfunction,aged,ovulation induction contraindications,leading to repeated implantation failure by a conventional stimulation protocol for IVF/ICSI. Methods:The differences between minimal stimulation and natural cycle were compared in embryo development,embryo implantation,clinical pregnancy and outcomes. Results:A total of 2 565 cycles completed IVF/ICSI-ET treatment during January 2010 to November 2012 which includes 1 752 minimal stimulation cycles and 813 natural cycles. The ratios of normal fertilization rate,cleavage rate and good quality embryos all tend to increase with the increase of cycle number. Conclusion:For patients with aged,ovulation induction contraindications,ovarian dysfunction and patients with previous poor ovarian response or low high-quality embryo rate,mild stimulation or natural cycle might be an optimal choice.