低氧训练对大鼠骨骼肌SDH和MDH活性的影响

探讨在低氧和运动训练应激作用下，大鼠骨骼肌琥珀酸脱氢酶（SDH）和苹果酸脱氢酶（MDH）活性的变化．雄性SD大鼠34只，随机分为常氧安静组（A）、常氧运动组（B）、低氧安静组（C）、低氧运动组（D）．分别进行常氧训练、低氧应激和低氧训练．在实验第4W末采样，测试大鼠股四头肌SDH和MDH的活性．经过4W的实验，低氧运动组SDH的活性高于A、B、C组．有显著性差异（P〈0．05）．低氧运动组MDH的活性也比A、B、C组高，但只与A、C组有显著性差异（P〈O．05）．4W周的持续低氧应激明显抑制了大鼠股四头肌SDH的活性．而低氧训练却能提高大鼠股四头肌SDH的活性．MDH的变化与SDH的变化相似，四周低氧训练也能显著提高大鼠股四头肌MDH的活性．

Effects of Hypoxia-training on The Activities of SDH and MDH in Skeletal Muscle of Rats

To investigate the change of activity of SDH and MDH in skeletal muscle of rats after hypoxia-training. 34 male adult Sprague-Drawly（SD） rats were randomly divided into 4 groups, normoxia non- exercise group（A）, normoxia exercise group（B）, hypoxia non--exercise group（C） and hypoxia exercise group（D）. They carried out normoxia-training, hypoxia stress and hypoxia-training. After 4 weeks, to sample and to test activity of SDH and MDH in skeletal muscle of rats. After 4 weeks＇ training, Activity of SDH of hypoxia--training group was significantly higher than other groups（ P 〈0.05）. Activity of MDH of hypoxia--training group was the highest of all groups, and was significantly different compared with A, C group（ P 〈0.05）. 4 weeks＂ hypoxia stress can inhibit activity of SDH of rats＇ quadriceps muscle of thigh obviously. But hypoxia-training can boost its activity. 4 weeks＇ hypoxia--training can boost activity of SDH of rats＇ quadriceps muscle of thigh obviously. And activity of MDH of rats＇ quadriceps muscle of thigh shows the same change, 4 weeks＇ hypoxia-training can boost activity of MDH of rats＇ quadriceps muscle of thigh obviously too.