绝经后妇女骨密度变化与活性氧的相关性研究

目的探讨活性氧与骨密度(BMD)的相关性,以进一步阐明活性氧与骨质疏松症的内在联系。方法选择符合纳入标准的绝经后妇女,测定其骨密度, 根据骨密度分为骨质疏松组、骨量减少组及正常组各30例。检测各组研究对象的血清丙二醛(MDA)、超氧化物歧化酶(SOD),比较各组之间的MDA、SOD的不同,分析MDA、SOD与BMD的相关性。结果骨质疏松组、骨量减少组的血清 MDA水平较正常组高而SOD含量降低,骨质疏松组的MDA和SOD亦较骨量减少组升高和降低(P<0．01);MDA与BMD呈负相关(r=-0．799,P<0．01),SOD与 BMD呈正相关(r=0．860,P<0．01)。结论活性氧增多可导致骨密度下降,活性氧可能参与和促进了骨质疏松症的病理过程。

The research of correlation betwen reactive oxygen species and bone mineral density in postmenopausal women

Objective To clarify the correlation between reactive oxygen species and bone mineral density(BMD). Methods This research selects postmenopausal women which fit the research's standard and examines their bone mineral density (BMD), and divides them into osteoporosis group, bone mass reduction group and normal group base on their BMD. Then we examine their serum malondialdehyde (MDA) and superoxide dismutase (SOD), compare the difference of MDA and SOD every group, analysis the correlation of MDA and SOD with BMD. Results Serum MDA level is much higher in osteoporosis group and bone mass reduction group than those in normal group( P<0. 01) ; Serum SOD level is much lower in osteoporosis group and bone mass reduction group than those in normal group( P < 0.01); MDA level is negatively correlated with BMD(r= - 0.799, P < 0.01) ,SOD level is positively correlated with BMD( r = 0. 860, P < 0. 01). Conclusion Reactive oxygen species can reduce BMD,it takes part in and accelerates course of osteoporosis.