How Tautological Are Interspecies Correlations of Carcinogenic Potencies? |
| |
| Authors: | David A Freedman Lois Swirsky Gold Thomas H Slone |
| |
| Institution: | 1 Statistics Department, University of California, Berkeley, California 94720.;2 Life Sciences Division, Lawrence Berkeley Laboratory, University of California, Berkeley, California 94720. |
| |
| Abstract: | Crouch and Wilson demonstrated a strong correlation between carcinogenic potencies in rats and mice, supporting the extrapolation from mouse to man. Bernstein et al. , however, show that the observed correlation is mainly a statistical artifact of bioassay design. Crouch et al. have a comeback. This paper will review the arguments and present some new data. The correlation is largely (but not totally) tautological, confirming results in Bernstein et al. |
| |
| Keywords: | Carcinogenic potency TD50 interspecies correlation one-hit model animal cancer tests |
|
|
