| 代谢综合征高危人群心血管危险因素综合干预的临床研究 |
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| 引用本文： | 高阳,陈思娇,魏敏,胡怡,熊盈,白小涓,徐锦春,李廷富,宋今丹. 代谢综合征高危人群心血管危险因素综合干预的临床研究[J]. 西南科技大学学报(哲学社会科学版), 2008, 6(1): 45-48 |
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| 作者姓名： | 高阳 陈思娇 魏敏 胡怡 熊盈 白小涓 徐锦春 李廷富 宋今丹 |
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| 作者单位： | 中国医科大学附属第一医院老年病教研室，中国医科大学附属第一医院老年病教研室，中国医科大学附属第一医院老年病教研室，中国医科大学附属第一医院老年病教研室，中国医科大学附属第一医院老年病教研室，中国医科大学附属第一医院老年病教研室，中国医科大学附属第一医院老年病教研室，中国医科大学附属第一医院老年病教研室，中国医科大学医学分子生物学研究所卫生部细胞生物学重点实验室 硕士研究生110001，硕士研究生110001，硕士研究生110001，硕士研究生110001，硕士研究生110001，硕士研究生110001，硕士研究生110001，硕士研究生110001 |
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| 基金项目： | 辽宁省沈阳市科技计划，辽宁省科技攻关计划，辽宁省自然科学基金 |
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| 摘 要： | 目的评价综合干预对代谢综合征高危人群心血管危险因素影响。方法对经常住院的100例代谢综合征高危患者进行综合干预,随访2年。另选一般临床资料相匹配,具有可比性的60例代谢综合征高危患者作对照组,评估综合干预前后即第0,1,2年腰围、体重指数、收缩压和舒张压、HDL-C、TG、LDL-C、空腹血糖、空腹胰岛素、胰岛素抵抗指数、C-反应蛋白的变化,并进行对照。结果干预组0年,1年,2年的比较,腰围、BMI、SBP和DBP、HDL-C、FBG、HOMA-IR、CRP的变化差异有统计学意义（P〈0.05）,而TG和LDL-C变化差异无统计学意义（P〉0.05）;对照组0年,1年,2年的比较,腰围、BMI、SBP和DBP、HDL-C、TG、LDL-C、FBG、FINS、HOMA-IR、CRP的变化差异均无统计学意义（P〉0.05）;干预组与对照组两组第2年比较,除TG和LDL-C外,腰围、BMI、SBP和DBP、HDL-C、FBG、HOMA-IR、CRP的变化差异有统计学意义（P〈0.05）。结论综合干预可改善代谢综合征胰岛素抵抗,提高胰岛素敏感性,降低CRP。
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| 关 键 词： | 代谢综合征(MS) 高危人群 心血管危险因素 综合干预 |
| 修稿时间： | 2007-12-18 |
Clinical Research in Intervention of High-risk Population of Metabolic Syndrome RiskFactors of Cardiovascular |
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| Gao Yang,Chen Sijiao,Wei Ming,Hu Yi,Xiong Ying,Bai Xiaojuan,Xu Jinchun,Li Tingfu,Song Jindan. Clinical Research in Intervention of High-risk Population of Metabolic Syndrome RiskFactors of Cardiovascular[J]. Journal of Southwest University of Science and Technology, 2008, 6(1): 45-48 |
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| Authors: | Gao Yang Chen Sijiao Wei Ming Hu Yi Xiong Ying Bai Xiaojuan Xu Jinchun Li Tingfu Song Jindan |
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| Affiliation: | Gao Yang,Chen Sijiao, Wei Ming,Hu Yi,Xiong Ying,Bai Xiaojuan,Xu Jinchun,Li Tingfu,Song Jindan(Teaching and Research Office for Geriatric Disease of the First Affiliated Hospital of China Medical University, Shenyang,110001,China; 2 Medical Molecular Biology Research Institute of China Medical University-Key Laboratory of Cell Biology of Ministry of Health ,Shenyang, 110001, China) |
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| Abstract: | Objective Evaluation of intervention in cardiovascular risk factors in the metabolic syndrome in high-risk crowds.Mehtods This study take comprehensive intervention of 100 cases recurrent hospitalization metabolic syndrome high-risk groups,following-up of 2 years.Choose another general clinical data matching,comparable 60cases of the metabolic syndrome in high-risk groups as the control group,before and after the intervention,evaluating the following projects,Namely,the changes of waist circumference,body mass index,systolic blood pressure and diastolic blood pressure,HDL-C,TG,LDL-C,fasting blood glucose,fasting insulin,the insulin resistance index,C-reactive protein in 0,1,2years,then compared.Results The comparation in intervention group in 0,1,2years:the changes in waist circumference,BMI,SBP and DBP,HDL-C,FBG,HOMA-IR,CRP had a statistical difference (P<0.05),while TG and changes in LDL-C was no statistical difference (P>0.05);the comparation in control group in 0,1,2years,the changes in waist circumference,BMI,SBP and DBP,HDL-C,TG,LDL-C,FBG,FINS,HOMA-IR,CRP had no statistical difference (P>0.05);the intervention group and the control group compared in the 2th years: Apart from LDL-C and TG,changes of waist circumference,BMI,SBP and DBP,HDL-C(mmol/L),FBG,HOMA-IR,CRP had a statistical difference (P<0.05).Conclusions Intervention can improve insulin resistance in metabolic syndrome,improve insulin sensitivity,decrease CRP. |
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| Keywords: | Metabolic syndrome(MS) Risk factors of cardiovascular High-risk Population Interventions |
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