Mortality modeling: A review |
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Authors: | Anatoli I Yashin Ivan A Iachine Alexander S Begun |
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Institution: | 1. Max Planck Institute for Demographic Research , Doberaner Strasse 114, Rostock, 18057, Germany;2. Center for Demographic Studies , Duke University , Box 90408, Durham, NC, 27708–0408, USA E-mail: yashin@demogr.mpg.de;3. Department of Demography and Statistics , Odense;4. Max Planck Institute for Demographic Research , Doberaner Strasse 114, Rostock, 18057, Germany |
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Abstract: | Looking at survival in terms of biological indicators of aging has given rise to various models of mortality, some of which we review here. The most notable models are that of Strehler and Mildvan, which relates the force of mortality to the ability of organisms to compensate for stress, and that of Sacher and Trucco, which describes the role played by homeostatic forces in shaping the age‐specific pattern of mortality. The analysis of longitudinal data in aging studies now incorporates the notions of heterogeneity and frailty, as well as that of changes in the “repair capacity”; of organisms. Furthermore, attention is now being paid to evolutionary theory and to models of senescence. These models and directions for further research are discussed. |
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Keywords: | Heterogeneity Frailty Homeostasis Repair capacity Antagonistic pleiotropy Evolution |
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