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Stochastic Modelling of Multiple Random Genetic Mutations Under the Cancer Stem Cell Hypothesis |
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| Authors: | CRISTIAN TOMASETTI |
| Institution: | 1. Department of Biostatistics , Harvard University and Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute , Boston , Massachusetts , USA cristian@jimmy.harvard.edu |
| Abstract: | The probability distribution for the size of each of the various cancer cell subpopulations created by random genetic mutations is expressed in the case of non-exponential growth of cancer and in the case of a heterogeneous tumor cell population. |
| Keywords: | branching processes genetic mutations stem cells tumor growth tumor heterogeneity |