Stochastic Modelling of Multiple Random Genetic Mutations Under the Cancer Stem Cell Hypothesis
Authors:
CRISTIAN TOMASETTI
Affiliation:
1. Department of Biostatistics , Harvard University and Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute , Boston , Massachusetts , USA cristian@jimmy.harvard.edu
Abstract:
The probability distribution for the size of each of the various cancer cell subpopulations created by random genetic mutations is expressed in the case of non-exponential growth of cancer and in the case of a heterogeneous tumor cell population.