Assessing interactions for fixed‐dose drug combinations in subcutaneous tumor xenograft studies |
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Authors: | Jianrong Wu |
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Affiliation: | Department of Biostatistics, St. Jude Children's Research Hospital, , Memphis, TN?38105 USA |
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Abstract: | Drug combinations in preclinical tumor xenograft studies are often assessed using fixed doses. Assessing the joint action of drug combinations with fixed doses has not been well developed in the literature. Here, an interaction index is proposed for fixed‐dose drug combinations in a subcutaneous tumor xenograft model. Furthermore, a bootstrap percentile interval of the interaction index is also developed. The joint action of two drugs can be assessed on the basis of confidence limits of the interaction index. Tumor xenograft data from actual two‐drug combination studies are analyzed to illustrate the proposed method. Copyright © 2013 John Wiley & Sons, Ltd. |
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Keywords: | bootstrap confidence interval drug– drug combination log10 cell kill interaction index right censoring |
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