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Bayesian hierarchical joint modeling using skew-normal/independent distributions
Authors:Geng Chen
Institution:Clinical Statistics, GlaxoSmithKline, Collegeville, PA, USA
Abstract:The multiple longitudinal outcomes collected in many clinical trials are often analyzed by multilevel item response theory (MLIRT) models. The normality assumption for the continuous outcomes in the MLIRT models can be violated due to skewness and/or outliers. Moreover, patients’ follow-up may be stopped by some terminal events (e.g., death or dropout), which are dependent on the multiple longitudinal outcomes. We proposed a joint modeling framework based on the MLIRT model to account for three data features: skewness, outliers, and dependent censoring. Our method development was motivated by a clinical study for Parkinson’s disease.
Keywords:Clinical trial  Item-response theory  Latent variable  MCMC  Parkinson’s disease
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