Sequential experimental design and response optimisation |
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Authors: | Luc Pronzato Éric Thierry |
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Affiliation: | (1) Laboratoire I3S, CNRS/Université de Nice-Sophia Antipolis, bat. Euclide, Les Algorithmes, 2000 route des Lucioles, BP 121, 06903 Sophia-Antipolis Cedex, France |
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Abstract: | We consider the situation where one wants to maximise a functionf(θ,x) with respect tox, with θ unknown and estimated from observationsy k . This may correspond to the case of a regression model, where one observesy k =f(θ,x k )+ε k , with ε k some random error, or to the Bernoulli case wherey k ∈{0, 1}, with Pr[y k =1|θ,x k |=f(θ,x k ). Special attention is given to sequences given by , with an estimated value of θ obtained from (x1, y1),...,(x k ,y k ) andd k (x) a penalty for poor estimation. Approximately optimal rules are suggested in the linear regression case with a finite horizon, where one wants to maximize ∑ i=1 N w i f(θ, x i ) with {w i } a weighting sequence. Various examples are presented, with a comparison with a Polya urn design and an up-and-down method for a binary response problem. |
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Keywords: | Adaptive control Bernoulli trials binary response dose-response optimum design parameter estimation response optimisation sequential design |
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