On misspecification of the dispersion matrix in mixed linear models

The general mixed linear model can be written y = Xβ + Zu + e, where β is a vector of fixed effects, u is a vector of random effects and e is a vector of random errors. In this note, we mainly aim at investigating the general necessary and sufficient conditions under which the best linear unbiased estimator for \varvec r(\varvec l, \varvec m) = \varvec l\varvec ￠\varvec b+\varvec m\varvec ￠\varvec u{\varvec \varrho}({\varvec l}, {\varvec m}) = {\varvec l}{\varvec '}{\varvec \beta}+{\varvec m}{\varvec '}{\varvec u} is also optimal under the misspecified model. In addition, we offer approximate conclusions in some special situations including a random regression model.