The application of stochastic approximation methods to the bio-assay problem |
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| Authors: | Dan Anbar |
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| Affiliation: | Case Western Reserve University, Cleveland, Ohio USA;Tel Aviv University, USA |
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| Abstract: | A new general model for the bio-assay problem is introduced. It is shown that when the slope of the dose-response curve and the median effective dose is known, the Robbins-Monro method yields an asymptotically optimal estimation procedure. Adaptive procedures are discussed for the case of unknown slope. Results of Monte Carlo studies are given. |
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| Keywords: | Efficient estimation quantal response estimation Monte Carlo studies |
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