Past-users of HRT are osteopenic four months after discontinuation:an observational and cross-sectional study |
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Authors: | Aubertin-Leheudre Mylène Mèlançon Michel O Chaput Jean-Philippe Dionne Isabelle J |
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Institution: | Research Centre on Aging, Faculty of Physical Education and Sports, University of Sherbrooke, Sherbrooke, Québec, Canada. |
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Abstract: | Hormonal replacement therapy (HRT) helps to prevent osteoporosis. The effect of short-term discontinuation of a long-term HRT on bone mineral density (BMD) in healthy post-menopausal women is unknown. Fifteen women on HRT (HRT users), 17 who never used HRT (non-users) and 8 former HRT users (past-HRT users) were recruited. BMD was measured by DXA. Our results allow to hypothesize that BMD may decline after short-term HRT discontinuation, which would increase the fracture risks. Indeed, our results show that past-HRT users are osteopenic just as non-users. However, these results should be re-examined using a prospective trial and a larger sample size. |
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