Affiliation: | 1. Department of Biostatistics and Computational Biology , University of Rochester Medical Center , 601 Elmwood Avenue, Box 630, Rochester , NY , 14642 , USA feng@bst.rochester.edu;3. Department of Biostatistics and Computational Biology , University of Rochester Medical Center , 601 Elmwood Avenue, Box 630, Rochester , NY , 14642 , USA |