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A response-adaptive design in crossover trial |
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| Authors: | Uttam Bandyopadhyay Atanu Biswas Shirsendu Mukherjee |
| Institution: | 1. Department of Statistics , University of Calcutta , 35 Ballygunge Circular Road, Kolkata , 700 019 , India ubstat@caluniv.ac.in;3. Applied Statistics Unit, Indian Statistical Institute , 203 B.T. Road, Kolkata , 700 108 , India;4. Department of Statistics , Behala College , Kolkata , 700 060 , India |
| Abstract: | In the present work, whenever the response variables are binary, we frame an adaptive allocation rule for a two-treatment two-period crossover design in the presence of possible carry-over effects. The proposed rule is a combination of the play-the-winner and randomized play-the-winner rules. We study various properties of the proposed rule through asymptotics and simulations. Some related inferential problems are also considered. The proposed procedure is compared with some possible competitor. |
| Keywords: | carry-over effect play-the-winner rule randomized play-the-winner rule urn model |