D-optimal designs for covariate models

The problem of finding D-optimal or D-efficient designs in the presence of covariates is considered under a completely randomized design set-up with v treatments, k covariates and N experimental units. In contrast to Lopes Troya Lopes Troya, J., 1982, Optimal designs for covariates models. Journal of Statistical Planning and Inference, 6, 373–419.], who considered this problem in the equireplicate case, we do not assume that N/v is an integer, and this allows us to study situations where no equireplicate design exists. Even when N/v is an integer, it is seen quite counter-intuitively that there are situations where a non-equireplicate design outperforms the best equireplicate design under the D-criterion.