Life events,genetic susceptibility,and smoking among adolescents |
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| Institution: | 1. Department of Cardiology, Austin Hospital, Melbourne, Victoria, Australia;2. Centre of Cardiovascular Research and Education in Therapeutics (CCRE), Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia;3. Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia;4. Department of Cardiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia;5. University of Melbourne, Melbourne, Victoria, Australia;6. Department of Cardiac Surgery, Austin Hospital, Melbourne, Victoria, Australia;7. Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia;8. Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong;9. Department of Cardiology, Prince of Wales Hospital, Hong Kong, China;10. Department of Surgery, Monash University, Melbourne, Victoria, Australia;11. Department of Cardiothoracic Surgery, Monash Medical Centre, Melbourne, Victoria, Australia |
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| Abstract: | Although stressful life events during adolescence are associated with the adoption of unhealthy behaviors such as smoking, both social circumstances and physical traits can moderate the relationship. This study builds on the stress paradigm and gene–environment approach to social behavior by examining how a polymorphism in the serotonin transporter gene 5-HTTLPR moderates the effect of life events on adolescent smoking. Tests of interaction hypotheses use data from the Family Transitions Project, a longitudinal study of 7th graders followed for 5 years. A sibling-pair design with separate models for the gender composition of pairs (brothers, sisters, or brother/sister) controls for unmeasured family background. The results show that negative life events are significantly and positively associated with smoking. Among brother pairs but not other pairs, the results provide evidence of gene–environment interaction by showing that life events more strongly influence smoking behavior for those with more copies of the 5-HTTLPR S allele. |
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| Keywords: | Adolescent smoking Negative life events Stress Gene–environment interaction 5-HTTLPR |
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