Absolute Risk or Relative Risk? A Study of Intraspecies and Interspecies Extrapolation of Chemical‐Induced Cancer Risk |
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| Authors: | Jeanne Kuo,Igor Linkov,Lorenz Rhomberg,Michael Polkanov,George Gray,& Richard Wilson |
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| Affiliation: | Department of Physics and Center for Risk Analysis, Harvard University, Cambridge, MA, USA. |
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| Abstract: | We have used the CBDS database of the National Toxicology Program to study the difference between absolute risk and relative risk models for interspecies and intersex predictions of cancer risk. For no combination (class) of tumor and site is the prediction good for all chemicals. The variation in predicted risk between chemicals exceeds the difference in risks resulting from application of these two models. On the whole, it appears that relative risk is a better model. |
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| Keywords: | Risk assessment tobacco smoke pollution health policy science evaluation |
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