Tuning Parameter Selection in Penalized Frailty Models

The penalized likelihood approach of Fan and Li (2001 Fan, J., Li, R. (2001). Variable selection via nonconcave penalized likelihood and its oracle properties. Journal of the American Association 96:1348–1360.Taylor &; Francis Online], Web of Science ®] , Google Scholar], 2002 Fan, J., Li, R. (2002). Variable selection for Cox’s proportional hazards model and frailty model. The Annals of Statistics 30:74–99.Crossref], Web of Science ®] , Google Scholar]) differs from the traditional variable selection procedures in that it deletes the non-significant variables by estimating their coefficients as zero. Nevertheless, the desirable performance of this shrinkage methodology relies heavily on an appropriate selection of the tuning parameter which is involved in the penalty functions. In this work, new estimates of the norm of the error are firstly proposed through the use of Kantorovich inequalities and, subsequently, applied to the frailty models framework. These estimates are used in order to derive a tuning parameter selection procedure for penalized frailty models and clustered data. In contrast with the standard methods, the proposed approach does not depend on resampling and therefore results in a considerable gain in computational time. Moreover, it produces improved results. Simulation studies are presented to support theoretical findings and two real medical data sets are analyzed.