Estimating the parameter in the Pauling equation

Four procedures are suggested for estimating the parameter ‘a’ in the Pauling equation:

e-X/a+e ? Y/a = 1.

The procedures are: using the mean of individual solutions, least squares with Y the subject of the equation, least squares with X the subject of the equation and maximum likelihood using a statistical model. In order to compare these estimates, we use Efron's bootstrap technique (1979), since distributional results are not available. This example also illustrates the role of the bootstrap in statistical inference.