首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Wavelet Thresholding Estimation in a Poissonian Interactions Model with Application to Genomic Data
Authors:Laure Sansonnet
Institution:Laboratoire de Mathématiques d'Orsay, Université Paris‐Sud
Abstract:This paper deals with the study of dependencies between two given events modelled by point processes. In particular, we focus on the context of DNA to detect favoured or avoided distances between two given motifs along a genome suggesting possible interactions at a molecular level. For this, we naturally introduce a so‐called reproduction function h that allows to quantify the favoured positions of the motifs and that is considered as the intensity of a Poisson process. Our first interest is the estimation of this function h assumed to be well localized. The estimator urn:x-wiley:03036898:media:sjos12009:sjos12009-math-0001 based on random thresholds achieves an oracle inequality. Then, minimax properties of urn:x-wiley:03036898:media:sjos12009:sjos12009-math-0002 on Besov balls urn:x-wiley:03036898:media:sjos12009:sjos12009-math-0003 are established. Some simulations are provided, proving the good practical behaviour of our procedure. Finally, our method is applied to the analysis of the dependence between promoter sites and genes along the genome of the Escherichia coli bacterium.
Keywords:adaptive estimation  interactions model  oracle inequalities  Poisson process  thresholding rule  U‐statistics  wavelets
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号