Which Life Domains Impact Most on Self-Rated Health? A Cross-Cultural Study of Switzerland and its Neighbors

General life satisfaction (GLS) is a strong health correlate and can be conceptualized as an aggregate of satisfactions in different life domains and as a proxy for quality of life. Little is known about which life domains—measured as domain satisfactions—contribute most to GLS and are the best predictors of self-rated health (SRH) and whether these associations differ between countries and/or language areas. We used stepwise logistic regression models to investigate how domain satisfactions, GLS and SRH are interrelated and compared German-speaking and French/Italian-speaking Switzerland with the corresponding neighboring countries of Germany, Austria, France and Italy. The associations of domain satisfactions with GLS and SRH varied significantly in magnitude and between countries and language areas. GLS was strongly related to self-rated health in all populations, but more so in the German-speaking than the French/Italian-speaking regions. Adjusted for all domain satisfactions, satisfaction with one’s financial situation and job satisfaction showed independent effects on SRH and were the most important predictors of GLS, although no clear geographical pattern emerged. Domain-specific satisfactions were similarly associated with GLS and SRH, but the strength of the association varied between German-, French- and Italian-speaking populations. Any similarity between Swiss language areas and neighboring countries was limited to German-speaking populations. Country- and language-specific life domain satisfactions may provide useful pointers for targeting policies in the respective domains.