| 不同致惊药物对小鼠不同脑区~3H-GABA与GABA_A受体结合的影响 |
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| 引用本文： | 周雪瑞,李晓煜,戚炜,徐项桂,朱剑琴.不同致惊药物对小鼠不同脑区~3H-GABA与GABA_A受体结合的影响[J].苏州科技学院学报(社会科学版),1999(4). |
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| 作者姓名： | 周雪瑞 李晓煜 戚炜 徐项桂 朱剑琴 |
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| 作者单位： | 淮阴师范学院生物系，南京大学生物科学与技术系，南京大学生物科学与技术系，苏州铁道师范学院生物系，南京大学生物科学与技术系 淮阴 223001，南京 210093，南京 210093，苏州 215009，南京 210093 |
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| 摘 要： | 用放射配体受体结合分析法,测定致惊药物红藻氨酸(kainic,KA)和印防己毒素(picrotoxin,Pic)对小白鼠下丘脑、大脑皮层、海马、小脑四个脑区~3H-GA-BA 和 GABA_A 受体结合的影响。结果显示,KA、Pic 均能明显降低各脑区~3H-GABA和 GABA_A 受体的结合量,除 Pic 对下丘脑无显著差异外,其余均有显著性差异(P<0.05或 P<0.01)。实验结果提示:KA 和 Pic 均能降低 GABA_A 受体的结合量,但是它们是通过不同的途径间接或直接地影响 GABA 能系统活动的。
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| 关 键 词： | 红藻氨酸 印防己毒素 GABA_A受体 ~3H-GABA |
Effects of Convulsant drugs on ~3H-GABA Binding with GABA_A Receptor in Different Areas of Brain in Mice |
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| Zhou Xuerui Li Xiaoyu Qi Wei Xu Xianggui.Effects of Convulsant drugs on ~3H-GABA Binding with GABA_A Receptor in Different Areas of Brain in Mice[J].Journal of University of Science and Technology of Suzhou:Social Science,1999(4). |
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| Authors: | Zhou Xuerui Li Xiaoyu Qi Wei Xu Xianggui |
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| Abstract: | This paper reported the effects of convulsant drugs of kainic acid and pi- crotoxin on the ~3H-GABA binding in four different areas in mice brain by using radioligand- receptor binding assay.The results showed that kainic acid markedly decreased the binding of ~3H-GABA to GABA_A receptor significantly(P<0.05 or P<0.01).In addition to hypotha- lamus(P>0.05),the effect of picrotoxin on the binding of ~3H-GABA tO GABA_A receptor had significant difference to cerebellum,hippocampus and cerebral cortex(P<0.05 or P< 0.01).These results suggested that kainic acid and pierotoxin can decrease the binding of GABA_A receptor.They may influence on the action of GABA-ergic system through directly or indirectly through different way. |
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| Keywords: | kainic acid picrotoxin GABAA receptor ~3H-GABA |
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