Sample Size and Power Calculation in Comparing Diagnostic Accuracy of Biomarkers with Pooled Assessments |
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| Authors: | Aiyi Liu Enrique F Schisterman Eric Teoh |
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| Institution: |
a National Institute of Child Health and Human Development, USA.
b University of Alabama at Birmingham, USA. |
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| Abstract: | When testing of a biomarker is costly, pooling of samples becomes a useful and efficient alternative (Faraggi et al., 2003). In this paper, we develop procedures for sample size and power calculations for planning a study comparing the accuracy of biomarkers in diagnosis of diseases with pooled samples. Explicit formulas are derived for several important pooling strategies. The effects of pooling samples on sample size and power of the test are also discussed. |
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| Keywords: | Area under the curve diagnostic biomarkers sensitivity specificity receiver operating characteristic curves |
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