基于细胞的生物传感器:用石英晶体微天平方法研究膜蛋白相互作用

在药物开发早期选择最优的候选目标物对于避免后期药物研发失败是至关重要的。Attana200细胞生物传感器能检测目标物在生物基质条件下的无标、全实时动力学情况,提供一个信息丰富的生物学相关的测量方法。细胞能在传感器表面生长,和传统传感器一样通过连续流引入相互作用的生物分子。该仪器还兼容标准生物传感器表面,而且可用于比较键合的纯化目标和相互作用的细胞。

Cell-Based Biosensors: A Quartz Crystal Microbalance Approach to Membrane Protein Interaction Studies

It is of the utmost importance to avoid late-failing drugs by selecting the best candidate early in the drug development process. The Attana Cell 200 biosensor measures label-free, full kinetics in real time with the target in its biological context, providing an information-rich approach to biologically relevant measurements. Cells can be grown directly on the sensor surface, and the interacting biomolecule is introduced to the continuous flow system as in a traditional biosensor. The instrument is also co...