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Optimal sampling times in population pharmacokinetic studies |
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| Authors: | Jonathan R Stroud Peter Müller & Gary L Rosner |
| Institution: | University of Chicago, USA,;Duke University, Durham, USA |
| Abstract: | We propose a simulation-based approach to decision theoretic Bayesian optimal design. The underlying probability model is a population pharmacokinetic model which allows for correlated responses (drug concentrations) and patient-to-patient heterogeneity. We consider the problem of choosing sampling times for the anticancer agent paclitaxel, using criteria related to the total area under the curve, the time above a critical threshold and the sampling cost. |
| Keywords: | Clinical trial Limited sampling strategies Longitudinal data Markov chain Monte Carlo methods Optimal design Population model |