An optimal sequential procedure in ethical allocation |
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| Institution: | 1. Crown Bioscience Inc., 3375 Scott Blvd, Suite 108, Santa Clara, CA 95054, USA;2. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China;3. HuMurine Technologies, Inc., 2700 Stockton Blvd, Rm. 1403, Sacramento, CA 95817, USA;2. Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC;3. Division of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland;4. Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland |
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| Abstract: | In this paper, given an arbitrary fixed target sample size, we describe a sequential allocation scheme for comparing two competing treatments in clinical trials. The proposed scheme is a compromise between ethical and optimum allocations. Using some specific probability models, we have shown that, for estimating the risk difference (RD) between two treatment effects, the scheme provides smaller variance than that provided by the corresponding fixed sample size equal allocation sampling scheme. |
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