D-efficient window experimental designs |
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Authors: | B. Bogacka P. Johnson B. Jones O. Volkov |
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Affiliation: | 1. School of Mathematical Sciences, Queen Mary, University of London, UK;2. Pfizer Limited, Sandwich Laboratories, UK |
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Abstract: | In the paper we present a new method of calculating sampling intervals, so-called windows, allowing an experimenter some flexibility in timing the sample collection, while a minimum required design efficiency for parameter estimation is assured. The method is based on the Equivalence Theorem for D-optimality what makes the length of each window related to the parameter sensitivities. An example of calculating the windows in a pharmacokinetic study is presented. Some other methods of calculating efficient sampling windows are briefly discussed. |
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Keywords: | Non-linear models D-optimum design The Equivalence Theorem |
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