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D-optimal designs for logistic models with three and four parameters
Authors:Gang Li  Dibyen Majumdar
Institution:1. GlaxoSmithKline, Collegeville, PA 19426, USA;2. University of Illinois at Chicago, Chicago, IL 60607, USA
Abstract:Logistic functions are used in different applications, including biological growth studies and assay data analysis. Locally D-optimal designs for logistic models with three and four parameters are investigated. It is shown that these designs are minimally supported. Efficiencies are computed for equally spaced and uniform designs.
Keywords:Local optimality  D-optimality  Nonlinear models  Growth curve  TT-system" target="_blank">gif" overflow="scroll">T-system  Saturated designs  Minimally supported designs
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