Backfitting Random Varying-Coefficient Models with Time-Dependent Smoothing Covariates

Abstract.  In this paper, we propose a random varying-coefficient model for longitudinal data. This model is different from the standard varying-coefficient model in the sense that the time-varying coefficients are assumed to be subject-specific, and can be considered as realizations of stochastic processes. This modelling strategy allows us to employ powerful mixed-effects modelling techniques to efficiently incorporate the within-subject and between-subject variations in the estimators of time-varying coefficients. Thus, the subject-specific feature of longitudinal data is effectively considered in the proposed model. A backfitting algorithm is proposed to estimate the coefficient functions. Simulation studies show that the proposed estimation methods are more efficient in finite-sample performance compared with the standard local least squares method. An application to an AIDS clinical study is presented to illustrate the proposed methodologies.