A Stochastic Two-Stage Model for Cancer Risk Assessment. II. The Number and Size of Premalignant Clones |
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| Authors: | Anup Dewanji David J Venzon Suresh H Moolgavkar |
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| Institution: | Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington 98104. |
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| Abstract: | Mathematical expressions are derived, under different dosing patterns, for the number and size of premalignant clones within the framework of a two-mutation model for carcinogenesis, which has previously been shown to be consistent with a large body of epidemiologic and experimental data. |
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| Keywords: | Two-stage model premalignant clones time-dependent dosing acute exposure |
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