| 气相色谱法测定盐酸美金刚有机溶剂的残留量 |
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| 引用本文： | 龚美义.气相色谱法测定盐酸美金刚有机溶剂的残留量[J].肇庆学院学报,2009,30(2):34-36. |
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| 作者姓名： | 龚美义 |
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| 作者单位： | 广东肇庆星湖生物科技股份有限公司,广东,肇庆,526070 |
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| 摘 要： | 采用毛细管气相色谱法,分析了盐酸美金刚合成中所用乙醇、乙醚、氯仿、乙酸乙酯的溶剂残留量.实验的色谱柱为HP-INNOWAX（30 m×0.53 mm×1.0μm）毛细管色谱柱,检测器为氢火焰离子化检测器（FID）.4种溶剂均达到完全分离,各溶剂线性实验所得回归方程的相关系数均大于0.99,加标回收率为90%～110%,RSD〈2.0%（n=6）.该方法准确、灵敏、重现性好.
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| 关 键 词： | 顶空毛细管气相色谱法 盐酸美金刚 残留有机溶剂 |
Determination of Residual Organic Solvents in Memantine Hydrochloride by Gas Chromatography |
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| GONG Meiyi.Determination of Residual Organic Solvents in Memantine Hydrochloride by Gas Chromatography[J].Journal of Zhaoqing University (Bimonthly),2009,30(2):34-36. |
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| Authors: | GONG Meiyi |
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| Institution: | GONG Meiyi (Star lake Bioseience Incorporated Company,Zhaoqing Guangdong 526070,China) |
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| Abstract: | Residual organic solvents of ethanol,ethyl ether,chloroform and acetic ether in memantine hydrochloride are determinated by capillary gas chromatagraphy. The procedure involves the use of a capillary chromatography column（HP-INNOWAX,30 m×0.53 mm×1.0 um） and FID detector. The result showes that 4 solvents are completely separated, the regression equation coefficients of 4 solvents are above 0.99, the recoveries are 90%-110% and the RSDs are less than 2.0% respectively. The method is accurate,sensitive and reproducible. |
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| Keywords: | headspace capillary gas chromatography memantine hydrochloride residual organic solvents |
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