|
|||||
|
|
Characterizing the Risk of Infection from Mycobacterium tuberculosis in Commercial Passenger Aircraft Using Quantitative Microbial Risk Assessment |
|
| Authors: | Rachael M Jones Yoshifumi Masago Timothy Bartrand Charles N Haas Mark Nicas Joan B Rose |
| Institution: | 1. Department of Fisheries and Wildlife, Michigan State University, East Lansing, MI, USA.
Department of Civil and Environmental Engineering, Tohoku University, Sendai, Japan.;2. Department of Civil, Architectural and Environmental Engineering, Drexel University, Philadelphia, PA, USA.;3. School of Public Health, University of California, Berkeley, CA, USA.;4. Department of Fisheries and Wildlife, Michigan State University, East Lansing, MI, USA. |
| Abstract: | Quantitative microbial risk assessment was used to predict the likelihood and spatial organization of Mycobacterium tuberculosis ( Mtb ) transmission in a commercial aircraft. Passenger exposure was predicted via a multizone Markov model in four scenarios: seated or moving infectious passengers and with or without filtration of recirculated cabin air. The traditional exponential ( k = 1) and a new exponential ( k = 0.0218) dose-response function were used to compute infection risk. Emission variability was included by Monte Carlo simulation. Infection risks were higher nearer and aft of the source; steady state airborne concentration levels were not attained. Expected incidence was low to moderate, with the central 95% ranging from 10 |
| Keywords: | Dose-response assessment environmental exposure immunologic risk assessment risk management tuberculosis |